Page 53 - PRECONGRESS COURSE 03

DNA is less condensed with more contacts with Lamin A in Fmn2 -/- Fmn2 +/-
5 μm
Fmn2 -/-
DNA Lamin A
Fmn2 +/-
Fmn2 +/-
**
Fmn2 -/-
Fmn2 -/-
d
** 5
0
10 8 6 4 2 0 ‐2
20 15 10
distance d centroid- outer DNA surface (μm)
% contacts Lamin A/DNA
Formin 2 and gene expression by RNA seq analysis
20 15
in Fmn2‐/‐ * 10
5
0
65 over‐
expressed
128 under‐ expressed in Fmn2‐/‐ *
* p<0.05 and more than 2 fold
‐5
‐5 0 5 10 15 20
LOG2 (Mean Fmn2 +/‐)
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 53
LOG2 (Mean Fmn2 ‐/‐)