Page 15 - PRECONGRESS COURSE 01

Some selected causes of impaired semen quality
• Testicular
– Idiopathic(Foetal?)
• Environment
• Lifestyle – Known
• Genetic
– Y-microdeletions
– Chromosomal
• Cryptorchidism
• Iatrogenic – cancer therapy
• Inflammation
• Pre-testicular
– Congenitale.g.Kallmann’s syndrome
– Acquired
• Tumour
• Vascular
• Androgens
• Post-testicular
– Congenital–e.g.CBAVD – Acquired
• Ejaculatory dysfunction
• Inflammation/Infection
• Vasectomy
• Auto-immune
Lund University / Faculty / Department / Unit / Document / Date
Increased sperm DNA damage in infertile men
• Several studies have shown that men from infertile couples have increased proportion of spermatozoa with DNA damage
Zini et al, Urology 2001
Lund University / Faculty / Department / Unit / Document / Date
Page 11 of 175
PRECONGRESS COURSE 01 I GENEVA, SWITZERLAND – 2 JULY 2017 15