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P-801 Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A
S. Mishra1, M. Van der Jeught1, M. Popovic1, J. Taelman1, E. Duthoo1, K. Szymanska2, P. De Sutter1, L. Tilleman3, F. Van Nieuwerburgh4, A.K. Boel1, S.M. Chuva de Sousa Lopes5, B. Heindryckx1
1Universitair Ziekenhuis Gent, Ghent-Fertility and Stem cell Team G-FaST- Reproductive Medicine, Gent, Belgium
2Ghent University, Basic Medical Sciences, Gent, Belgium
3Ghent University, Laboratory of Pharmaceutical Biotechnology- Faculty of Pharmaceutical Sciences, Gent, Belgium
4Ghent University, Laboratory of Pharmaceutical Biotechnology- Faculty of Pharmaceutical Sciences, Gent, Belgium
5Leiden University Medical Centre, Department of Anatomy and Embryology, Leiden, The Netherlands
P-802 Differentiating mouse embryonic stem cells into primordial germ cell-like cells and early meiotic stages by exposure to adult interstitial and neonatal testicular cells
A. Trout1, P. Xie1, Z. Rosenwaks1, G.D. Palermo1
1Weill Cornell Medicine, The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, U.S.A.
P-803 Activation of endogenous Steroidogenic factor 1 (SF-1) expression in 46,XY human pluripotent stem cell-derived gonadal-like cells guides the development of testicular cell fates
K. Sepponen1, D. Balboa2, K. Lundin1, T. Tuuri1, J. Tapanainen1
1University of Helsinki and Helsinki University Hospital, Obstetrics and Gynaecology, Helsinki, Finland
2University of Helsinki, Research Programs Unit- Molecular Neurology and Biomedicum Stem Cell Centre, Helsinki, Finland
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