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P-446 LH in vitro treatment promotes DNA repair of mouse apoptotic follicles damaged by alkylating agents
L.M. Castillo1,2, A. Buigues1,2, M. Marchante1,2, V. Rossi3, J. Martinez1,2, F.G. Klinger3, A. Pellicer4,5, S. Herraiz1,5
1IVI Foundation, Innovation, Valencia, Spain
2University of Valencia, Department of Pediatrics- Obstetrics and Gynecology, Valencia, Spain 3University of Rome Tor Vergata, Departament of Biomedicine and Prevention, Rome, Italy 4IVI-RMA, IVI Rome, Rome, Italy
5IIS La Fe, Reproductive Medicine, Valencia, Spain
P-447 Fertility preservation for prepubertal boys: evaluation of controlled slow freezing of testicular prepubertal tissues
M. Safrai1, D. Kabiri1, M. Gropp2, T. Mordechai Daniel3, G. Hidas4, T. Imbar3, B. Reubinoff5 1Hadassah-Hebrew University Medical Center- Ein-Kerem, Obstetrics and Gynecology, Jerusalem, Israel
2Hadassah-Hebrew University Medical Center- Ein-Kerem, The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel
3Hadassah-Hebrew University Medical Center- Ein-Kerem, Infertility and IVF Unit, Jerusalem, Israel
4Hadassah-Hebrew University Medical Center- Ein-Kerem, Department of pediatric Urology, Jerusalem, Israel
5Hadassah-Hebrew University Medical Center- Ein-Kerem, Department of Obstetrics & Gynecology & The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy, Jerusalem, Israel
P-448 Glycogen synthase kinase 3β inhibitor (iGSK3β) decreases cisplatin-induced oocyte death in vitro inhibiting TAp63 activation
V. Rossi1, A. Stefandottir2, A. Merolla2, F. Lopes2, G. Ingrosso3, R. Miceli3, M. Tuppi4, V. Doestch4, R.A. Anderson5, M. De Felici1, N. Spears2, F.G. Klinger1
1University of Rome TorVergata, biomedicin and prevention, Roma, Italy
2University of Edinburgh, School of Biomedical Sciences, Edinburgh, United Kingdom
3General Hospital Tor Vergata- Italy, General Hospital Tor Vergata- Italy, Rome, Italy
4Goethe-Universität Frankfurt am Main, Buchmann Institute for Molecular Life Sciences- Goethe- Universität Frankfurt am Main, Frankfurt, Germany
5University of Edinburgh, MRC Centre for Reproductive Health, Edinburgh, United Kingdom
P-449 Effect of sphingosine-1-phosphate on activation of dormant follicles in ovarian tissue from mouse and human
S.E. Pors1, L. Harðardóttir1, S.G. Kristensen1, C.Y. Andersen1 1Rigshospitalet, Laboratory of Reproductive Biology, Copenhagen, Denmark
P-450 Why the differences in the oocyte survival rate in a donor vitrified program?
S. Cortés Gallego1, A. Guijarro Ponce2, A. Rodrigo Carbajosa1, C. Andrés Santé1, C. Cordero Rosales1, R. Pandolfi1, M. Saladino2, J. Muñoz Ramirez1
1Clínica Tambre, Madrid, Madrid, Spain 2Clínica Tambre, Cuenca, Cuenca, Spain
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