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O-281 Effect of MVT-602, a potent kisspeptin receptor agonist, on luteinizing hormone (LH) concentrations in healthy pre-menopausal women undergoing a minimal controlled ovarian stimulation (COS) protocol
A. Abbara2, I. Duijkers3, M. Ezzati4, C. Voors-Pette5, C. Romeijn6, L. Berman7, X. Fan8, E. Migoya1, W.S. Dhillo2
1Myovant Sciences- Inc., Early Clinical Development, Brisbane, U.S.A.
2Imperial College London, Section of Investigative Medicine, London, United Kingdom 3Dinox Consultancy bv, None, Groningen, The Netherlands
4Palo Alto Medical Foundation, Reproductive Endocrinology and Fertility, Palo Alto, U.S.A. 5QPS Netherlands BV, Medical Operations, Groningen, The Netherlands
6QPS Netherlands BV, Clinical Pharmacology Unit, Groningen, The Netherlands
7Develop BioPharma Consulting, None, Barcelona, Spain
8Myovant Sciences- Inc., Biostatistics, Brisbane, U.S.A.
O-282 Granulosa cell signaling-based bioassay in vitro for personalized stimulation in ART
E. Paradiso1, C. Lazzaretti1, S. Sperduti1, L. Riccetti1, A. Nicoli2, M.T. Villani2, J. Daolio2, M. Lispi3, E. Gravotta3, G. Orlando3, M. Simoni1, L. Casarini1
1University of Modena and Reggio Emilia, Unit of Endocrinology- Dept. Biomedical- Metabolic and Neural Sciences, Modena, Italy
2Arcispedale Santa Maria Nuova, Department of Obstetrics and Gynaecology- Fertility center, Reggio Emilia, Italy
3Merck KGaA, Merck Serono S.p.A - Rome- Italy, Darmstadt, Germany
O-283 Pharmacokinetics and pharmacodynamics of a new recombinant human chorionic gonadotropin (rhCG) in healthy women and men after single and multiple subcutaneous administration
L.E.B. Kyhl1, P. Larsson2, K. Bruzelius3, B. Mannaerts4
1Ferring Pharmaceuticals A/S, Translational Medicine, Copenhagen, Denmark
2Ferring Pharmaceuticals A/S, Global Biometrics, Copenhagen, Denmark
3Ferring Pharmaceuticals A/S, Department of Bioanalysis, Copenhagen, Denmark
4Ferring Pharmaceuticals A/S, Reproductive Medicine and Women’s Health, Copenhagen, Denmark
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SCIENTIFIC PROGRAMME WEDNESDAY, 26 JUNE