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Learning Objectives
At the conclusion of this presentation, participants should be gain familiarity with:
1. 2. 3. 4.
Thyroid hormones & relevance for reproductive biology
Thyroid autoimmunity –prevalence, antibodies and reproductive associations Screening tests – what & when & for whom
Pre IVF Management – considerations, rationale & approaches
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Meaningful Reads
• Alexander EK, Pearce EN, Brent GA, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27:315–389.
• Abalovich M, et.al. 2010 The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism. Thyroid 20:1175–1178.
• Haddow JE, et. al. J 2004 The reference range and within-person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy. J Med Screen 11:170–174.
• Haddow JE, et al. 1999 Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549–555.
• Lazarus JH, Bestwick JP, Channon S, et al. Antenatal thyroid screening and childhood cognitive function. N Engl J Med. 2012;366:493–501Negro R, et.al. 2006 Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab 91:2587–2591.
• Rotondi M, et al. 2017 ATA guidelines on management of thyroid dysfunctions in pregnancy: what do OB/GYNs need to know? Gynecol Endocrinol. 2019 Feb 5:1-4.
• Spyridoula M, et. al. Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism, Thyroid. 2016 Jul 1; 26(7): 980–986.
• YunYing C et al. Outcome of in vitro fertilization in women with subclinical hypothyroidism. Reprod Biol Endocrinol. 2017; 15: 39. Published online 2017
• Mannisto T, Surcel HM, Ruokonen A, et al. Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid. 2011;21:291–298.
• Korevaar TI et.al. Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies. J Clin Endocrinol Metab. 2017 Jan 1;102(1):69-77.
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