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General remarks from Prof. Hayashi:
- The difference in efficiency for creating pups depending on the source of pluripotent stem cells used (3.5% from ES cells or 0.9% from iPS cells).
- Some of these animals gave birth to a second generation of mice.
- The maturation is critical in oogenesis in vitro; many of the in vitro oocytes generated are immature, have low mitochondria copy number and are more frequenty aneuploid than found in vivo oocytes.
- The extracellular matrix (ECM) plays an important role in the dormant state of primordial follicles, which can also be produced in culture.
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PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 53
