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The leading applications for pluripotent stem cell derivatives.
Trounson and Dewitt, 2016
Differentiation
• Retinal pigment epithelium • A9 dopaminergic neurons • Oligodendrocytes
• Pancreatic β-islet cells
• Cardiomyocytes.
PCC Stem Cells - ESHRE Vienna 2019
Clinical trials
hESC derivatives:
• Age-related macular degeneration (AMD) • Type I diabetes
• Spinal cord injury
• Myocardial infarct
• Parkinson disease
hiPSC derivatives:
• AMD
• Myocardial Infarct
Clinical trials with hESC-derivatives
Spinal cord injury/Macular degeneration
Geron corp.: hESC-derived oligodendrocytes, spinal cord injury. Oct.2010- Nov.2011. 5 patients
Advanced Cell Technologies: hESC-derived retinal pigment epithelium. Nov. 2010. Stargardt’s macular dystrophy and ARMD
PCC Stem Cells - ESHRE Vienna 2019
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PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 123
