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Baker et al., 2016
Chromosomal abnormalities
• Many recurrent abnormalities, due to selective advantage in undifferentiated state
• Often similar aberrations in cancers
• Effect on differentiation?
Differentiation potential of hPSC
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Chromosomal abnormalities: chromosome 1
Well studied in solid tumours → bad prognosis
hESC lines with 1q amplification (in complex karyotypes!)
• Oncogenes ↗ , tumour suppressor genes ↘, Wnt signaling ↘
• In vivo differentiation capacity ↘ and preference for ectoderm differentiation
• •
↳ suggests selective advantage over euploid cells Yang et al., 2010; Varela et al., 2012
• 1q amplifications become enriched during neural differentiation
Differentiation potential of hPSC
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PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 99
