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The ovarian reserve
Chemotherapy Radiotherapy
Birth
Premature ovarian failure
Wallace and Kelsey, Plos One, 2010
Risk of infertility after treatment
High risk >80%
Medium risk
Low risk < 20%
Total body irradiation
Leukaemia
Leukaemia
Pelvic irradiation
Cerebral tumor >24 Gy
Cerebral tumor <24 Gy
Bone marrow transplantation
Non- Hodgkin’s lymphoma
Wilms’ Tumor
Hodgkin’s lymphoma: alkylant agents
Hodgkin’s lymphoma: without alkylating agents
Germinal cell tumor (no radio)
Ewing’s Sarcoma no metast.
Osteosarcoma
Hepatoblastoma
Neuroblastoma
Wallace et al., Lancet Oncol , 2005
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