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Aim of the study
To assess whether the extent and the type of chromosomal mosaicism may influence the development potential of mosaic embryos
Prospective study involving assessment of embryos obtained from 2295 PGT cycles, performed from May 2016-May 2018
The clinical outcome after the transfer of mosaic embryos was evaluated comparing different groups of mosaic embryos and euploid embryos
Experimental Design The Part 2 of the study was organized into two steps.
Step 1: Validation of NGS for mosaicism detection: cell mixing experiments at different ratios of euploid and aneuploid cells to mimic chromosomal mosaicism.
Step 2: prospective evaluation of the clinical outcome obtained after transfer of mosaic embryos, diagnosed with NGS-based PGT-A.
Spinella et al. 2017 Fertil Steril 2018;109:77-83
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