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3 cycles of IUI + ovarian stimulation with FSH Eligible couples identified during clinic consultation Randomized 1 cycle of IVF Primary outcome : Live birth rate/couple Secondary outcome: Clinical pregnancy rates, Multiple pregnancy rate, OHSS rates and ‘treatment avoided” IUI vs IVF Nandi et al, Fertil Steril 107,1329,2017 Outcomes IUI + COH group (n = 101) IVF group (n = 106) RD (95% CI) RR (95% CI) Singleton live birth rate (per couple) n (%) 25 (24.7) 33 (31.1) 6.4% (−5.8% to 18.6%) 1.3 (0.81–1.96) Live birth rate (per couple) n (%) 29 (28.7) 36 (33.9) 5.2% (−7.4% to 17.8%) 1.8 (0.78–1.77) Clinical pregnancy rate (CPR per couple) n (%) 34 (33.6) 49 (46.2) 1.3 (0.97–1.93) Multiple pregnancy rate (per live birth) n (%) 4 (13.8) 3 (8.3) 0.6 (0.14–2.4) Miscarriage/CPR n (%) 3 (12%) 13 (26.5) 2.2 (0.69–7.05) Ectopic pregnancy (n) 2 0 Spontaneous conception leading to live birth n (%) 5 (4.9%) 12 (11.3) OHSS 0 3 (3.7) 126 123