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Maternal Smoking and Offpring Fertility
• 24 human first-trimester testes, aged 37-68 days post-conception, obtained from women undergoing legal termination of pregnancy . Historical controls.
• Testes exposed to maternal smoking:
• reduction in the number of germ cells: 55% [74-21%] P = 0.004
• Reduction in number of somatic cells by 37% [ 59-3%] P = 0.023
• The effect of maternal smoking was dose-dependent
• The number of germ cells in embryonic gonads, irrespective of gender, was also significantly reduced by 41% (95% CI 58-19%, P = 0.001) in exposed versus non-exposed embryonic gonads.
Mamsen et al Hum Rep 2010 25:2755
Challenges : Partner
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