Page 83 - ESHRE2019
P. 83
Immunohistochemistry: CD‐138
• Plasmacyte marker CD138 (also known as syndecan‐1, a transmembrane type heparan sulfate proteoglycan) is the most reliable and time‐saving diagnostic method for CE.
• Much superior in detection of ESPC to conventional tissue staining using methyl green pyronin, H&E (odds ratio 2.8; sensitivity, 100% versus 75%; specificity, 100% versus 65%)
• Less inter‐observer (96% versus 68%) and intra‐observer variability (93% versus 47%).
• Caution in clinical use: Endometrial epithelial cells constitutively express CD138 on the basolateral sides of their plasma membrane.
The reported prevalence of CE in endometrial biopsy specimens has varied considerably, ranging from 3% to 60%.
(Liu et al., Fertil Steril 2018)
78
PRECONGRESS COURSE 06 I VIENNA, AUSTRIA – 23 JUNE 2019 81
