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uNK‐Cells in RSA and infertile patients
RSA
Seshadri S, Sunkara SK; Hum Reprod Update. 2014
Infertile patients
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Association between pNK‐ and uNK‐cells
Anatomical Risk‐factors
(vag. sonography, hysteroscopy)
• synechia
• myomas
• polyps
• Uterine malformations
Hemostasiological Risk‐factors
• Protein C, S
• Factor VIII
• Antithrombin III‐deficiency
• Factor‐V‐Leiden
• Prothrombin and MTHFR
Autoimmunological Risk‐factors
• ANA
• Anti‐Cardiolipin‐antibodies
• Anti‐ß2‐Glycoprotein
• Lupus Anticoagulans
• Thyroid‐autoimmune‐diseases
Endocrine Risk‐factors
• PCOS
• Hyperprolactinaemia
• Corpus‐luteum‐Insufficiency • Hypo‐/Hyperthyreosis
Immunological diagnostic:
• Day of cycle 19‐22: • pNK‐cells
• uNK‐cells
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