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Case Presentation
• 30 yr old with 1 term delivery followed by 4 miscarriages <10 wks (1 trisomy 16, other 3 euploid)
 Standard RPL evaluation negative Further evaluation? Endometrial biopsy
• Negative for chronic endometritis
• Endometrial gland cells: Cyclin E expression
Endocrine Treatment: Luteal start vaginal micronized progesterone 100-200 mg q12h, LH +3 days → 10 wks
Subsequent Live Birth Rates:
68% per pregnancy Rx progesterone vs. 51% (OR 2.1 (95%CI 1.0-4.4)
Thank you!
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