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Multicenter study according to ER status
Retrospective, multicenter cohort study (7 Institutions)
333 cases with pregnancy after breast cancer
874 non pregnant controls matched for ER, stage, adjuvant treatment, age, year at diagnosis (+ healthy mother effect)
Primary endpoint: DFS ER+ pts.
(Two sided test a= 5% , b=20% , 226 events and 645 pts for HR 0.65)
Secondary endpoints: DFS in ER‐ pts., OS
Subgroup analysis: DFS according to timing of pregnancy DFS according to breastfeeding
Azim HA Jr et al. JCO 2013; Lambertini M et al. JNCI 2018.
Multicenter study according to ER status
DFS in ER+ patients Median F‐UP: 7.2 years
Azim HA Jr et al. JCO 2013; Lambertini M et al. JNCI 2018.
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