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miRNA as potential biomarkers?
However:
• Stage III‐IV
• Small sample size
• Microarray did not confirm other studies
• Controls had pathology
• No confirmation study
• No validation study
Cosar et al., Fertil Steril 2016
Mitochondrial mutations as potential biomarkers?
• Multiple mitochondria per cell
• Each mitochondrion contains multiple of copies of mitochondrial genome
• 16,569 bp containing 37 genes encoding 13 proteins, 22tRNAs, 2rRNAs
• Mutation rate about 100‐fold higher than in nuclear genome
Taylor RW et al., Nat Rev Genet 2005
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