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So, how do we fit these puzzle pieces together?
There are many overlapping pathways that lead to COPCs
Central Sensitization
- +
Peripheral Sensitization
Chronic Overlapping Pain Conditions
Viscero‐ viscero sensitization
Genetic variability
early life trauma environment
Stress response, HPA dysregulation
psychological factors
Immuno- inflammatory dysfunction
Inflammation Neuroangiogenesis
Viscero‐
somatic sensitization
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PRECONGRESS COURSE 03 I VIENNA, AUSTRIA – 23 JUNE 2019 17
Peripheral Factors
Central Factors