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Long non-coding RNA and endometriosis
• Limited studies
o Sun et al 2014, Ghazal et al 2015, Wang et al 2015, Wang et al 2016, Wang et al 2016
• Potential role in pathophysiology
o Hormone regulation in endometrium
o IGF, TNF, Wnt, MAPK and TGFB1 pathways o HOXA10 regulation
• Potential role in diagnosis of endometriosis o Endometrial biopsy
o Circulating lnc-RNA
Panir et al. HRU 2018
Wang et al 2016
• Discovery phase
o Pooled samples
• Serum endometriosis (n=10)
• Serum control (n=10)
• Eutopic EM endometriosis (n=5)
• Eutopic EM control (n=5)
• Ectopic EM (n=5)
o Transcriptome array
• Validation phase
o Endometriosis (n=59) and controls (n=51) o Serum
o RT-qPCR- 16 lncRNAs
Wang et al. Scientific Reports 2016
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