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PLCζ stimulates oocyte activation
PLCζ is the soluble oocyte‐activating factor (SOAF) released by sperm in the ooplasm
Ca2+ Ca2+ Ca2+
Ca2+
Ca2+ Ca2+ Ca2+
Ca2+
Links of PLCζ and fertilisation failure
Sperm defects are the leading cause of fertilisation failure
FF due to defective forms/abnormal function/no expression of PLCζ
Differences in PLCζ total levels and localisation
may explain male‐factor infertility and oocyte activation failure. (Yelumalai et al 2015 Fert Stert)
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