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In vitro fertilisation process
Day 0
Day 1 16‐18h
Normal fertilisation
ICSI ≈70% of MII injected IVF: 53‐81% of COC insem
ICSI Low fert: <25% of MII injected Total fert failure: 1‐5% of ICSI cycles
Kashir 2010, Vermeulen 2017
Incubator ?
Fertilisation
 Union of an oocyte and a spermatozoon to give rise to a zygote
 Fertilization is a ‘‘choreography’ of complex and highly coordinated
processes.
 Dictates the hundreds of different cell types and the positional information for the ~1012 cells that constitute a human being
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PRECONGRESS COURSE 02 I VIENNA, AUSTRIA – 23 JUNE 2019 23