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Cells excluded from compaction often have a chromosome complement different from trophectoderm cells
• Self‐correction mechanisms?
• Implication for biopsy
Lagalla et al., 2017
Hippo
Concluding remarks
Exciting new developments from studies on the formation of the blastocyst
• Cell fate detemination (Hippo, cell‐to‐cell contacts)
• Inner/outer cell allocation (cortical tension)
• Compaction (filopodia)
• Blastocoel formation (zippering of cell‐to‐cell contact)
New evidence from morphokinetics/PGT‐A investigation
• Pattern of cleavage are very important, irrespective of general morphology
• Self‐correctiontoeliminateaneuploid/abnormalcells?
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