Page 41 - ESHRE2019
P. 41
IVFOutcomeandSDF
ART outcome by method of fertilization
Pregnancy by Method in Cases of High Sperm DNA Fragmentation
42%
26%
IVF ICSI
Bungumet al. Hum Reprod 2007
Meta-analysis of 16 studies and 2,969 couples
Increased miscarriage in couples undergoing IVF/ICSI with high SDF
Risk ratio (RR) = 2.16
95% CI: 1.54-3.03; p<0.00001
Robinson et al. Hum Reprod 2012
Esteves, 29
Differences between IVF and ICSI concerning SDF
ICSI:
• Little sperm incubation before injection
• Oocyte cytoplasm (SDF repair mechanisms)
IVF:
• Prolonged culture (SDF increases with incubation time and temperature)
Lewis Middle East Fertil Soc J 2013; Dumoulin et al HR 2010
Esteves et al. 2018
Esteves, 30
35
PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 39
