Page 28 - ESHRE2019
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Learning objectives
Understand sperm DNA damage and how to measure it.
Appraise the evidence concerning the clinical utility of sperm DNA fragmentation testing in specific clinical scenarios.
Form judgment about how to act in situations where sperm DNA fragmentation values are abnormal.
Esteves, 3
Clinical relevance of sperm DNA damage
Common in infertile men and male partners of couples
attending ART programs
Esteves et al. 2015; Bungum et al. 2007
Reduced fecundability (longer time-to-pregnancy), recurrent pregnancy loss
Spano et al. 2000; Zini et al. 2011; Buck et al. 2014; ESHRE guidelines RPL 2017
Reduced reproductive outcomes (IUI and ART)
Zhao et al 2014; Simon et al. 2017; Zini et al. 2011
Transfer sperm genetic defect via ART, thus potentially affecting health of resulting offspring
Aitken et al, Nature 2004; TAU 2017
Esteves, 4
Esteves, 4
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