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P-580 Comparison of mitochondrial DNA content in euploid and aneuploid embryos at cleavage stage and blastocyst stage with NGS
A. Liñán Tegedor1, A. Bayram2, A. Arnanz1, I. Elkhatib3, C. Rubio4, C. Rupali5, N. Garrido6, H. Fatemi7, B. Lawrenz8
1IVI Middle East Fertility Clinic LLC, IVF Laboratory, Abu Dhabi, Spain
2IVI Middle East Fertility Clinic LLC, IVF Laboratory, Abu Dhabi, Turkey
3IVI Middle East Fertility Clinic LLC, IVF Laboratory, Abu Dhabi, Jordan 4Igenomix Foundation- Valencia- Spain, Genetic laboratory, Valencia, Spain 5Igenomix Dubai- United Arab Emirates., Genetic laboratory, Dubai, India 6IVI Valencia, IVI Foundation, Valencia, Spain
7IVI Middle East Fertility Clinic LLC, Medical Director, Abu Dhabi, Iran
8IVI Middle East Fertility Clinic LLC, Scientific Director, Abu Dhabi, Germany
P-581 Whole-genome methylomic profiling of iPSC-derived granulosa-like cells and adult granulosa cells implicates novel pathophysiological pathways of polycystic ovarian syndrome
C.C. Huang1, M.J. Chen1, S.U. Chen1, H.N. Ho1, Y. Yu-Shih1,2
1National Taiwan University Hospital, Obstetrics and Gynecology, Taipei City, Taiwan R.O.C.
2Fu Jen Catholic University Hospital, Department of Obstetrics and Gynecology, New Taipei City, Taiwan R.O.C.
P-582 Optimized NGS based protocol for the detection of small duplications/deletions in preimplantation embryos from carriers of balanced translocations and inversions
C.M. Garcia Pascual1, L. Navarro-Sánchez1, L. Martínez-Merino1, L. Rodrigo2, C. Simón3, C. Rubio1 1Igenomix, PGS Research, Valencia, Spain
2Igenomix, PGD Molecular Cytogenetics, Valencia, Spain
3University of Valencia- INCLIVA- Igenomix, Obstetrics and Gynecology, Valencia, Spain
P-583 Exome sequencing in a consanguineous family including spontaneous ovarian hyper- stimulation cases with unknown triggers
S. Viville1,2, E. Yagmur3, F. Mantar4, M. Ben-Rhouma2, M. Gultomuk5, N. Findikli6, M. Bahceci7, J. Muller8,9, O. Okutman1,2
1Hôpitaux Universitaires de Strasbourg- Nouvel hôpital civil, Laboratoire de diagnostic génétique- UF3472 Infertilité, Strasbourg, France
2Université de Strasbourg- Institut de Parasitologie et Pathologie Tropicale, EA 7292- Fédération de Médecine Translationelle, Strasbourg, France
3Erbil Yagmur Infertility Clinic, Infertility, Istanbul, Turkey
4Bahcesehir University, Department of Endocronology and Metabolism, Istanbul, Turkey
5Bahceci Health Group, Research and Development, Istanbul, Turkey
6Bahceci Fulya IVF Center, Embryology Laboratory, Istanbul, Turkey
7Bahceci Health Group, IVF Department, Istanbul, Turkey
8Université de Strasbourg- Laboratoire de Génétique Médicale, INSERM U1112- Fédération de Médecine Translationnelle de Strasbourg FMTS, Strasbourg, France
9Hôpitaux Universitaires de Strasbourg, Laboratoire de Diagnostic Génétique, Strasbourg, France
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