Page 48 - Eshre 2018

Abteilung Gynäkologische Endokrinologie und Reproduktionsmedizin, Bern
Risk of GnRH agonists in hormone receptor positive breast cancer?
TEXT: GnRHa with chemotherapy, SOFT: GnRHa after chemotherapy
Michael von Wolff Regan et al., Ann Oncol, 2017
Abteilung Gynäkologische Endokrinologie und Reproduktionsmedizin, Bern
GnRH depot agonists – when to start?
Advantages
Disadvantages
At the time of ovulation trigger
Early application
Risk of OHSS increased? Intervention with ovulation trigger?
At the time of aspiration
Timing of GnRH application can adapted in relation to the individual risk of OHSS
Risk of OHSS increased (personal communication)
A few days after aspiration
No risk of OHSS
Late application
It is unknown when GnRH agonists should be applied. According to experiences of many centers, application at the time of oocyte triggering seem to be a good option.
Michael von Wolff
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