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The stroma and vasculature are also targets
Green: Masson stain for collagen Focal cortical fibrosis in ovaries exposed to chemotherapy
Normal control After chemotherapy
Prominent thickening and hyalinization, with narrowing /obliteration of the lumen
Meirow D et al. Hum. Reprod. 2007;22:1626-1633
Risks of chemo agents to fertility
High risk Medium risk Low risk
Cyclophosphamide Ifosfamide Chlormethine Busulfan Melphalan Procarbazine Chlorambucil Mechlorethamine Carmustine Lomustine
Cisplatin Carboplatin Doxorubicin Dacarbazine Thiotepa Gemcitabine Cytarabine Daunorubicin
Vincristine Methotrexate Dactinomycin Bleomycin Mercaptopurine Vinblastine Azathioprine Fludarabine Etoposide
Adapted from ASCO guidelines and others
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