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Safety Concerns with Cytoplasmic Transfer
• mRNAs, proteins, organelles and other factors
• Only 10‐15% of mt replaced
• Heteroplasmy:
– Donor mitochondria identified only in half of the
embryos & placenta
– Only 2/15 children carried donor mitochondria
• Of the 23 pregnancies:
– 2 Turner (1 sp. Ab and 1 twin)
– One child developed pervasive disorder
Autologous Mitochondria from Oogonial Precursor Cells (OPCs)
• Describedinovariancortex
• Unipotent,germlinecells
• Becauseofslowself‐renewingnature,proposedtobe less predisposed to age‐related mitochondrial damage
Nature Med. 2004
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