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Prepubertal banking in 47,XXY ?
About 50% of pre-pubertal KS boys
have (few) testicular spermatogonial stem cells
• but 50% of KS adults have testicular spermatozoa Q: will we not remove precursors for the future?
• banking implies reduction of Leydig cells Q: what about development and puberty?
Prepubertal banking in 47,XXY ?
• extensive sclerosis and atrophy of seminiferous tubules occurs in majority of patients
Q: is auto-transplantation an option?
• stem cells produce sperm in adult KS via “X-correction” Q: are XXY prepubertal stem cells predestined to undergo apoptosis
Q: are they able to differentiate ?
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PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 65
