Page 22 - PCC10

NCT01344993
Clinical trials with hPSC-derived cells
no
NCT01217008
NCT01345006
NCT01469832
NCT01625559
NCT01674829
NCT01691261
NCT02057900
NCT02239354
NCT02286089
NCT02302157
NCT02445612
NCT02452723
NCT02463344
NCT02464956
NCT02590692
NCT02749734
disease
SCI
AMD
SMD
SMD
SMD
AMD
AMD
IHD
T1DM
AMD
SCI
SMD
PD
AMD
AMD
AMD
AMD; SMD
cell origin
hESC
hESC
hESC
hESC
hESC
hESC
hESC
hESC
hESC
hESC
hESC
hESC
phESC
hESC
hiPS autol
hESC
hESC
device
GRNOPC1
MA09‐ hRPE
MA09‐ hRPE
MA09‐ hRPE
MA09‐ hRPE
MA09‐ hRPE
PF‐ 05206388
VC‐01TM
OpRegen
AST‐OPC1
MA09‐ hRPE
ISC‐hpNSC
MA09‐ hRPE
CPCB‐RPE1
ESC‐RPE
derived cells
oligodendrocytes
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
CD15+ Isl‐1+ progen.
βcell progenitors
retinal pigmented epith.
oligodendrocits progenit.
retinal pigmented epith.
neural stem cells
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
retinal pigmented epith.
sponsor
Asterias Biotherapeutics
Astellas Inst. Regen.Med.
Astellas Inst. Regen.Med.
Astellas Inst. Regen.Med.
CHABiotech CO., Ltd
CHABiotech CO., Ltd
Pfizer
Assistance Pub. Hôp. Paris
ViaCyte
Cell Cure Neurosciences
Asterias Biotherapeutic.
Astellas Inst. Regen.Med.
Cyto Therapeutics Pty Lim.
Astellas Inst. Regen.Med.
Moorfields Eye Hosp. NHS
Regenerative Patch Tech.
Southwest Hospital, China
country
USA
USA
USA
UK
Korea
Korea
UK
France
USA
Israel
USA
USA
Australia
USA
UK
USA
China
phase
I
I/II
I/II
I/II
I
I/IIa
I
I
I/II
I/II
I/II
I/II
I
I/II
I
I/II
I
start date
Oct‐10
Apr‐11
Apr‐11
Nov‐11
Sep‐12
Sep‐12
Jun‐15
Jun‐13
Sep‐14
Mar‐15
Mar‐15
Jul‐12
Mar‐16
Jul‐12
Jul‐15
Oct‐15
May‐15
final date
Jul‐13
Aug‐15
Aug‐15
Sep‐15
Jun‐15
Apr‐16
Nov‐16
Jun‐18
Jan‐21
Sep‐19
Dic‐18
Dic‐29
Mar‐19
Dic‐29
Apr‐16
Sep‐22
Dec‐17
no pac.
5
13
13
12
3
12
10
6
40
15
35
13
12
11
10
20
15
status
completed
completed
completed
completed
unknown
unknown
ongoing
recruiting
ongoing
recruiting
recruiting
ongoing
recruiting
ongoing
unknown
recruiting
recruiting
PCC Stem Cells - ESHRE BCN 2018
Clinical trials with hPSC-derived cells
NCT02755428
AMD
hESC
MA09‐ hRPE
retinal pigmented epith.
Chinese Academy Sc.
China
I
Apr‐17
Dec‐20
10
recruting
NCT02903576
AMD; SMD
hESC
retinal pigmented epith.
Federal Univ. São Paulo
Brazil
I/II
Aug‐15
Jun‐19
18
recruiting
NCT02923375
GVHD
hiPSC allog
CYP‐001
MSC
Cynata Therapeutics
Australia
I
Mar‐17
Sep‐19
16
recruiting
NCT02941991
SMD
hESC
MA09‐ hRPE
retinal pigmented epith.
Astellas Inst. Regen.Med.
UK
I/II
Jun‐13
Dec‐19
11
ongoing
NCT03046407
AMD
hESC
ESC‐RPE
retinal pigmented epith.
Chinese Academy Sc.
China
I
Mar‐17
Dec‐20
10
recruiting
NCT03119636
PD
hESC
neural precursors
Chinese Academy Sc.
China
I/II
May‐17
Dec‐20
50
recruiting
NCT03162926
T1DM
hESC
VC‐02
βcell progenitors
ViaCyte
USA
I
Jul‐17
Jun‐18
15
recruiting
NCT03163511
T1DM
hESC
VC‐02
βcell progenitors
ViaCyte
USA
I/II
Jul‐17
Dec‐20
55
recruiting
ChiCTR‐OCB‐15005968
SOSD
hESC
Corneal‐epithelium
Eye Institute Xiamen Univ.
China
I/II
Oct‐15
Dec‐18
20
recruiting
ChiCTR‐OCB‐15007054
AMD
hESC
ESC‐RPE
retinal pigmented epith.
Chinese Academy Sc.
China
I
Jun‐16
Jun‐17
10
recruiting
ChiCTR‐OCB‐15007055
RPD
hESC
ESC‐RPE
retinal pigmented epith.
Chinese Academy Sc.
China
I
Sep‐15
Dec‐17
10
recruiting
AMD
hiPSC allog
retinal pigmented epith.
RIKEN Center for Dev.Biol
Japan
I
Feb‐17
5
recruiting
UMIN000011929
AMD
hiPS autol
retinal pigmented epith.
RIKEN Center for Dev.Biol
Japan
I
Sep‐14
Sep‐15
1
suspended
PD
hiPSC allog
dopamine‐secreting nerve
Center for iPS Cel Res.
Japan
I
2018
PCC Stem Cells - ESHRE BCN 2018
Page 16 of 135
22