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CD133+ cells
Highly conserved stem cell glycoprotein antigen (Prominin-1)
Maker for identification of early immature of Endothelial Progenitor Cells (EPCs) (Gehling UM et al. Blood 1997)
Advanced Therapy Medicinal Product (ATMP) used in Regenerative Medicine (EMA)
No evidence of abnormal tissue formation, calcification, edema or
oncogenic potential after more that 300 animal experiments (Bongiovanni et al.Stem cells and development 2014)
Mechanisms of Action (MoA)
CD133+
Paracrine mechanisms
Tissue Regeneration Tissue Remodelling Neoangiogenesis
Bongiovanni et al. Stem cells and development, 2014
Endometrial Differentiation/ Cell fussion
Resident Endometrial Stem Cell Recruitment/ Activation
Endothelial Differentiation
Modulation of
inflammation
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Matrix Remodelling Factors
Pro‐angiogenic Factors
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