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79% of de novo mutations arise on the paternal allele Father Mother
Informative SNP
DNM
Informative SNP
G G
G G
Same read = same allele
5,640 de novo mutations paternal allele
1,576 de novo mutations maternal allele
4%
80%
Child
16%
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28,577 unphased de novo mutations
Parental age effects on number of de novo mutations
Number of DNMs in child
Paternal age effect ~0.93 DNMs/year
Number of DNMs on the maternal allele in the child
Age of the father at conception
Age of the mother at conception
Age of the mother at conception
Also the number of de novo mutations in the maternal germline increase with advancing age! Goldmann et al. Nat Genet 2016
Maternal age effect
̴ 0.25 DNMs/year
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