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Timing of de novo mutations and (disease) biology
Timing of de novo mutations matters!
Bone marrow
Colon Skin
Post‐natal life
Germline mutations
Fetal development
Postzygotic mutations
Early post‐zygotic
Embryonic development
Somatic mutations
Acuna‐Hidalgo, Veltman & Hoischen. Genome Biology 2016. Slide courtesy: R. Acuna‐Hildalgo
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