Page 101 - PCC08
P. 101
Research in human embryos
PCC Genetics - ESHRE BCN 2018
Embryo genome editing- Limitations
Corrected
• Genome editing of human embryos requires the use of PGD in order to identify the modified embryos from the non modified or the one’s with off-target effects. Sequencing of the full genome required.
• Generation of chimera/mosaic embryos as a result of inefficient nuclease cutting and/or inaccurate DNA repair before the embryo undergoes cleavage will remain undetected.
PCC Genetics - ESHRE BCN 2018
Page 95 of 102
PRECONGRESS COURSE 08 I BARCELONA, SPAIN – 1 JULY 2018 101
