Page 49 - PCC07

Flowchart of the ERGO Study Population
(Meun et al, 2017, Unpublished data)
40 30 20 10
0
• Inclusion between 45 and 55 years of age
• Venous blood collected at age 55 and all Sex steroids
were measured with LC-MS/MS
• About40differentdimensionsareassessedevery5 year (amongst them CAC, PWV, PAD etc.)
• Disease (CVD, Type II DM etc.) incidence is recorded from patient history files
• Averagefollow-upisabout15–20yearsfromintakeat 55 yrs
• Pre-existentCVDincludedandexcludedintwosimilar analyses
• Totalcohortsizewith20yearsoffollow-upis approximately 9000 individuals with about 5000 women
< 14 yr
15-24 yrs
25 - 44 yrs
45 - 64 yrs
>65 yrs
Baseline Characteristics of PCOS vs. Controls
(Meun et al, 2017 unpublished data)
PCOS, N = 106 Controls, N = 171 P-value
Age (years)
69.57 (8.72)
69.20 (8.60)
0.73
Age at menopause (years)
51.00 (3.85)
50.19 (3.92)
0.09
Years since menopause (years)
18.56 (9.19)
19.00 (10.15)
0.71
Waist / hip ratio
0.89 (0.08)
0.86 (0.08)
0.01
BMI (kg/m2)
27.92 (4.53)
26.84 (3.83)
0.03
Current smoking, n (%)
17 (16.0%)
28 (16.4%
0.94
Systolic Blood Pressure (mmHg)
142.30 (21.74)
143.61 (19.22)
0.60
Diastolic Blood Pressure (mmHg)
74.55 (10.39)
77.03 (9.92)
0.05
Hypertension, n (%)
70 (66.0%)
107 (62.6%)
0.56
Cholesterol (nmol/l)
5.98 (0.85)
6.09 (1.01)
0.34
HDL Cholesterol (mmol/l)
1.40 (0.35)
1.57 (0.39)
<0.01
Triglyceride (mmol/l)
1.62 (0.86)
1.39 (0.62)
0.02
Lipid lowering medication, n (%)
8 (7.5%)
24 (14.0%)
0.10
Fasting blood glucose (mmol/l)
6.25 (1.83)
5.79 (1.41)
0.03
Diabetes Mellitus
20 (18.9%)
12 (7.0%)
<0.01
Prevalent CVD
7 (6.6%)
11 (6.4%)
0.96
SHBG (nmol/l)
43.58 (33.36 - 78.25)
63.00 (57.70 - 69.70)
<0.01
Estradiol (pmol/l)
38.77 (21.23 -69.41)
29.44 (18.35 - 58.61)
0.06
Androstenedione (nmol/l)
2.63 (2.00 - 3.31)
2.17 (1.67 - 2.88)
0.01
DHEA (nmol/l)
9.12 (6.13 - 14.14)
8.68 (6.20 - 12.24)
0.68
Testosterone (nmol/l)
1.30 (1.04 - 1.71)
0.74 (0.68 - 0.80)
<0.01
FAI
2.69 (2.13 - 3.49)
1.16 (1.05 - 1.29)
<0.01
Page 42 of 196
PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 49