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Obesity amplifies insulin resistance in women with PCOS
Insulin sensitivity
BMI
(Adapted from Holte et al, J Clin Endocrinol Metab 1994, 78 1052)
Overweight/obese women with PCOS are more symptomatic than lean PCOS subjects
100 80 60 40 20
0 oligo/amenorrhoea
≤25 (321) >25 (329)
normal
PCO
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hirsutism
Franks S, Int J Obes 2008 32 1035-41
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