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Health consequences in PCOS offspring
Insulin resistance Diabetes T2 Cardiovascular diseases
Increased ovarian volume
Higher AMH concentration Higher prevalence of PCOS
Oxidative stress
Hyperandrogenism Obesity
Bias for data analysis
o PCOS diagnostic criteria
o End points
o Type of population
o Treatments in pregnancy (medical or diet) o Multiple pregnancy
o Exclusion of preexisting factors
o Lack of pre-pregnant BMI and matching for this factor
o No stratification of preterm delivery for cause, spontaneous Vs induced preterm delivery o paucity of prospective studies
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Kahsar-Miller et al, Fertil Steril 2001; Crisosto et al JCEM 2007; Sir-Petermann T. et al, JCEM 2009; Recabarren et al, JCEM 2008
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