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Prospective Dose Finding Study Amer, Li & Cooke, Humam Reprod 2003
The modified Monte Carlo Up-and-Down design
– 30 women divided into ten groups, each group with 3 women
– Dose in each group to be determined by the response of previous group
– Energy utilised for each puncture is standardised
80% 70% 60% 50% 40% 30% 20% 10%
0%
56%
67%
puncture
Conception rates after LOD Sheffield Prospective Study
17%
1
234
1
234
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