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Presentation of polycystic ovary syndrome
• Classic presentation is with symptoms of anovulation (amenorrhoea, oligomenorrhoea, irregular cycles) associated with symptoms (hirsutism, acne, alopecia) and/or biochemical evidence of hyperandrogenism
• However spectrum of presentation includes anovulatory women without hirsutism and hirsute
women with regular cycles (“Rotterdam” diagnostic criteria: Hum Reprod, 2004 19 1-7)
Prevalence of PCO and PCOS
• PCO in 20-25% of “normal” (mainly Europid) population but higher in populations of south Asian origin
(Polson et al, Lancet 1988 1(8590):870-2; Clayton et al, Clin Endocrinol 1992 37:127-34; Rodin et al, Clin Endocrinol 1998, 49:91-9)
• PCOS (NIH definition) in 4-8% of “unselected” population of white and black subjects
(Knochenhauer et al, J Clin Endocrinol Metab, 1988 83:3078-82)
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