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Metformin Protects Against OHSS in PCOS IVF Treatment (long not short protocol)
No benefit for live birth rate
Tso et al, Cochrane Sys Rev, 2014 Jacob et al, Hum Rep 2016
OR 0.29 (0.18, 0.49)
Conventional IVF
Gonadotrophin hCG OR ET
GnRH agonist
progesterone
0 7 14 21 28 35 42 49 56 63
GnRH antagonist
Gonadotrophin hCG or GnRH agonist progesterone
Short
Similar live birth rate
Collection - transfer 50% reduction OHSS
(OR 0.53, 95% C 0.30 to 0.95) days Can program with COCP or P4
Al-Inany et al, Cochrane 2016:CD001750 Lambalk et al HRU 2017; 23:560
oestradiol
OR ET
GnRH antagonist
0 7 14 21 28
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