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SHOULD WE ACCEPT LESSONS FROM THE BOVINE MODEL?
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CONCLUSIVE REMARKS
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Bovine proteome/genome is more like human than that of mouse :
̶ Media conditioned by bovine embryos may be analysed in search for embryotropins,
which may be evolutionary conserved
In vivo gold standard indicates goal which should be achieved
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Sensitive marker for chromosomal instability : further research may elucidate mechanisms using in vivo and in vitro embryos
Sensitive marker for changes in gene expression and epigenetic changes : further research may be aimed at testing human embryo culture media with in vivo and in vitro bovine embryos
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Bovine embryo development is more like human (sensitive) than that of mouse :
̶ Novel culture techniques, like microfluidics, can be optimized first with bovine embryos
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