Page 58 - Eshre 2018

microRNA as potential biomarker?
Voorhoeve et al., 2006 Also Eini et al., 2013
Overview pathology GCNIS related TGCT.
COMMON PRECURSOR
PRE-INVASIVE:
miR-371-3/302/367
GCNIS (GB-DSD)
Blocked PGC/gonocyte (EMBRYONIC GERM CELL)
Early gonadal development
seminoma embr. carc.
INTRATUBULAR:
70%
miR-371-3/302/367
~ 7 years
INVASIVE:
PURE or MIXED
seminoma
miR-371-3/302/367
AFP
miR-371-3/302/367
yolk sac tum.
germ cells
PLURIPOTENT (TOTI-/OMNI-)
embr.carc.
teratoma
hCG
miR-371-3/302/367
choriocarc.
58
Page 52 of 130