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PSC-derived (male) gametes: how far are we?
Can human PSCs can form FUNCTIONAL gametes?
-We don’t know
-Unethical test germline transmission in chimeric animals -Testing inter-species chimerism pigs for “organ farming”
Patient PSCs
PDX1 -/- pig blastocyst CRISP-CAS
pig with patient pancreas
Wu et al., Cell 2017
Chuva de Sousa Lopes 9
PSC-derived (male) gametes: how far are we?
Germline?
Wu et al., Cell 2017
Chuva de Sousa Lopes 10
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