Page 20 - Eshre 2018
P. 20
Sexual differentiation of the gonads in mouse
Ovary
‐ only subtle changes ‐ germ cell nests form
Testis
‐ intensive proliferation ‐ cell migration
‐ vascularisation
‐ testis cords formation ‐ fetal Leydig cells
Intensive male‐specific cell proliferation and ingression
E11.2 – 11.4 – mediated by FGF9/FGFR2 – expansion of Sertoli cell and interstitial progenitors E11.4 – 12.5 – mediated by PDGF/PGDFRα – interstitial precursors
After E12.5 – no ingression ‐ tunica albuginea formation
20
Page 14 of 130
