Page 134 - Eshre 2018
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Part V: Results
MiRNA abundance in embryonic culture media following embryo transfer
621 miRNAs Present in Culture media
102 miRNAs (P<0.05)
70 miRNAs had significantly lower expression intensity in samples from embryos leading to pregnancy
Samples with positive outcome had a decreased miRNA repertoire
The best marker was miR-29c-3p with adjusted P-value of 0.019 and an AUC value of 0.83
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Part V: Results
• The number of extracellular vehicles was lower in SCM with positive outcomes (3.8 × 109/mL EVs), as compared to a negative outcome (7.35 × 109/mL EVs) possibly explaining the reduced number of miRNAs in the SCM associated with failed pregnancies.
10 9 8 7 6 5 4 3 2 1 0
negative outcome
positive outcome
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Particles/mL*109
