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P. 11
XX E12.0
FOXL2
Ovary E13.5
XX
XX E12.5
OCT4 FOXL2 OCT4
E11.5
OCT4 XY XY E12.0
SOX9
XY E12.5
OCT4 SOX9 OCT4
Testis E13.5
♀♂
Ovary 3 month
Testis
3 month
OCT4
OCT4
The origin of primordial germ cells in mouse
ExE
VE epi
PGCs arise in the epiblast near extraembryonic ectoderm (ExE) and visceral endoderm (VE)
E6.25 – signals: BMPs from ExE and VE, and WNT from VE E7.5 – first PGCs (about 40 cells) at the base of allantois
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PRECONGRESS COURSE 01 I BARCELONA, SPAIN – 1 JULY 2018 11
