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P-287 Pharmacokinetics, pharmacodynamics, and safety of relugolix, a potent oral once-daily gonadotropin-releasing hormone (GnRH) receptor antagonist, as monotherapy and in combination with estradiol/norethindrone acetate add-back therapy.
A. Lukes1, B. Johnson2, L. Jones2, J. Berg3, R. Williams4, B. Bock5, K. Morton6, A. Langenberg7, P. Mudd Jr8
1Carolina Women's Research and Wellness Center, GYN, Durham, U.S.A. 2Roivant Sciences, Clinical Pharmacology, Durham, U.S.A.
3DaVita Clinical Research, Minneapolis, U.S.A.
4DaVita Clinical Research, Denver, U.S.A.
5WCCT Global, Costa Mesa, U.S.A.
6QPS, Spring eld, U.S.A.
7Independent Consultant, Ross, U.S.A.
8Roivant Sciences, Clinical Research, Durham, U.S.A.
P-288 Anatomical visualization of inferior hypogastric nerves during uterosacral ligamentectomy for deep in ltrating endometriosis contributes to the prevention of postoperative dysuria
K. Watanabe1, M. Ichikawa1, T. Shiraishi1, N. Terada1, Y. Shirai1, H. Kaseki1, M. Yonezawa1, S. Ono1,
T. Ichikawa1, Y. Kuwabara1, S. Akira1, T. Takeshita1
1Nippon Medical School, Ob/Gyn, Tokyo, Japan
P-289 Is pregnancy the panacea for pain symptoms associated with endometriosis?
D. Alberico1, G. Barbara2, F. Facchin3, P. Mosconi4, A. Roberto4, D. Dridi2, E. Somigliana5, P. Vercellini5
1Fondazione IRCCS"Ca'Granda"-Ospedale Maggiore Policlinico, Clinica Ostetrico-Ginecologica "L. Mangiagalli", Milan, Italy
2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Milan, Italy 3Catholic University, Department of Psychology, Milan, Italy
4IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Department of Public Health, Milan, Italy 5Università degli Studi di Milano, Department of Clinical Sciences and Community Health, Milan, Italy
P-290 Epigenetic alteration of Thymic Stromal Lymphopoietin, TSLP, in endometriosis
S. Habibi1,2, E. Amirchaghmaghi3,4, F. Ramezanali4, R. A atoonian4, P. Afsharian1, M. Shahhoseini1
1Department of Genetics- Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine- ACECR, Tehran, Iran
2Faculty of Basic Sciences and Technologies, University of Science and Culture- ACECR, Tehran, Iran
3Department of Regenerative Biomedicine- Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology- ACECR, Tehran, Iran
4Department of Endocrinology and Female Infertility- Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine- ACECR, Tehran, Iran
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