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Serum LH levels during COS
Retrospective n=619
Multiple LH measurements / LH cut‐off 0.8 mIU/ml increased rate of pregnancy loss for an increase in episodes of low LH OR 1.55 (95% CI: 1.046–2.302, P = 0.029)
LH exposure during COS
AUC 6.94 ± 0.28 mIU/ml 11.47 ± 0.30 mIU/ml, P < 0.001
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Do we need to measure E2 levels during COS?
Nine RCTs, n=3352
No evidence to support or deny the value of E2 assessment on the day of hCG
Kosmas et al. 2004
Prospective cohort study n=127
Elevated estradiol level (>757 pg/ml) on the day of antagonist initation is associated with lower implantation and ongoing pregnancy rates.
Nayak et al 2012
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