Page 81 - PRECONGRESS COURSE 04

Mouse embryo attachment to epithelium: trophoblast transcription factor responses
Might embryo stress eg arising from handling and culture in ART impact on implantation?
• Repeated hyperosmolar stress promotes breaching through the JNK signalling pathway
• Evidence broadly suggests that embryonic stressors actually advance trophoblast differentiation, depleting stem cell reserves (‘survival at a cost’)
• The effect may be to promote the epithelial phase of implantation
Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4. Rappolee et al Biol Reprod. 2016;95(5):110. PMID: 27683262
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 81